In 1993, Meg Ryan and Tom Hanks reunited for their second film together: 'Sleepless in Seattle,' a film that would go on to become one of the greatest romantic comedies of all time. Inspired by 'An Affair to Remember,' the film follows widower Sam (Hanks), whose son calls into a radio talk show and convinces his father to talk about his wife, attracting a woman named Annie (Ryan). But before the pair can come together, they'll endure a seemingly endless string of mix-ups and personal complications, of course. 20 years later, we revisit the cast of this classic and see what they're up to now. 

Tom Hanks, Sam Baldwin

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Then: Tom Hanks played Sam Baldwin, a lonely widower whose son calls into a radio show and urges him to talk about his wife in hopes that might attract the perfect woman. Dennis Quaid was also considered for the male lead. Hanks and Meg Ryan had starred together previously in 'Joe Versus the Volcano,' though Ryan wasn't the first choice for the role of Annie Reed.

Now: Hanks recently appeared in 'Captain Phillips' and can be seen next as Walt Disney in 'Saving Mr. Banks,' the story of the making of 'Mary Poppins.'

Meg Ryan, Annie Reed

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Then: As previously mentioned, Ryan wasn't the first choice for the part of Annie Reed, the engaged woman who feels as though something is missing from her relationship -- that's when she hears Sam's story on the radio and writes him a letter.

Julia Roberts, Kim Basinger, Michelle Pfeiffer, and Jodie Foster all turned down the part before it went to Ryan.

Now: Ryan and Hanks reunited again for 'You've Got Mail' in 1998. Since then, Ryan has appeared in 'Proof of Life,' 'Kate and Leopold,' and 'In the Land of Women.' She has a recurring role on Lisa Kudrow's series 'Web Therapy.'

Bill Pullman, Walter

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Then: Bill Pullman played Walter, Annie's fiance. Pullman and his 'Sleepless and Seattle' co-stars Hanks and Rosie O'Donnell had previously all appeared together in 'A League of Their Own.'

Now: Pullman is known for his roles in films like 'Independence Day' and 'Lost Highway,' and recently appeared in 'Lola Versus.' He also starred on the recent short-lived NBC comedy '1600 Penn,' in which he played the president.

Ross Malinger, Jonah Baldwin

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Then: Ross Malinger played Jonah Baldwin, Sam's son who fashions himself a meddling little matchmaker for his father. A young Jason Schwartzman also auditioned for the part.

Now: Malinger went on to appear in 'Bye Bye Love,' 'Sudden Death,' and 'Party of Five.' One of his last roles was in an episode of the CBS series 'Without a Trace' (pictured above right). He left acting shortly after and managed a car shop in California until it closed in 2009.

Rosie O'Donnell, Becky

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Then: Rosie O'Donnell played Becky, Annie's friend. When Annie is hesitant to mail her letter to Sam, Becky does it for her.

Now: O'Donnell had her own daytime talk show throughout the 90s and appeared in films like 'The Flintstones' and 'Harriet the Spy.' She currently stars on the ABC Family series 'The Fosters.'

Gaby Hoffmann, Jessica

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Then: Gaby Hoffmann played Jessica, Jonah's friend who helps him try to unite his dad and Annie. Hoffmann had also starred in the films 'Uncle Buck' and 'Field of Dreams.'

Now: Hoffmann reunited with O'Donnell for 'Now and Then,' and appeared in films like 'Volcano' and '200 Cigarettes' before taking some time off from acting in the early 00s. She returned in recent years, appearing in 'Louie,' 'Crystal Fairy,' the upcoming 'Veronica Mars' film, and the new season of 'Girls,' premiering in January.

Victor Garber, Greg

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Then: Victor Garber played Greg, Sam's brother-in-law.

Now: Garber went on to have roles in films such as 'Titanic' and 'Legally Blonde,' and starred on the series 'Alias.' He recently appeared in 'Argo.'

Rita Wilson, Suzy

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Then: Rita Wilson played Suzy, Sam's sister. In real life, Wilson and Hanks met on the set of the 1985 film 'Volunteers' and married in 1988.

Now: Wilson went on to star in 'Now and Then' with Gaby Hoffmann and Rosie O'Donnell, and appeared in 'That Thing You Do,' which was directed and written by, and starred Hanks. Her last film credit is the 2011 movie 'Larry Crowne,' which starred Hanks in the title role.

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