Woody Harrelson and Laura Dern in ‘Wilson’ Red Band Trailer

You know those actors you’ve always wanted to see reunite in a movie but never thought in your wildest dreams you’d get the chance? Woody Harrelson and Laura Dern both co-starred in 2005’s The Prize Winner of Defiance, Ohio, and now they’re together again for Wilson, a comedy from The Skeleton Twins director Craig Johnson. Johnson has proven to be adept at handling complicated family relationships while keeping a wry sense of humor the whole time, and in its first trailer, Wilson looks to be just that.

Wilson is adapted from a graphic novel of the same name by Daniel Clowes, who also wrote the screenplay. Harrelson is perfectly odd and awkward in the trailer, a paragon of those lost middle-aged screwups always present in Johnson’s films. Dern is wearing those ’90s rocker chick outfits, and is the perfect perpetually horrified foil for Harrelson’s various blunders. The trailer also features character actress Margo Martindale, and sharp-eyed It’s Always Sunny in Philadelphia fans may be able to spot a less-sweaty Ryan McPoyle (Nate Mooney) onscreen for a second or two. Judy Greer and Cheryl Hines also star.

Here’s the official synopsis:

Harrelson stars as Wilson, a lonely, neurotic and hilariously honest middle-aged misanthrope who reunites with his estranged wife and gets a shot at happiness when he learns he has a teenage daughter (Isabella Amara) he has never met. In his uniquely outrageous and slightly twisted way, he sets out to connect with her.

Wilson opens in theaters March 24, 2017.